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Article

A Novel Recombinant Anti-CD22 Immunokinase Delivers Proapoptotic Activity of Death-Associated Protein Kinase (DAPK) and Mediates Cytotoxicity in Neoplastic B Cells.

Molecular cancer therapeutics - 1 May 2016

Lilienthal Nils, Lohmann Gregor, Crispatzu Giuliano, Vasyutina Elena, Zittrich Stefan, Mayer Petra, Herling Carmen Diana, Tur Mehmet Kemal, Hallek Michael, Pfitzer Gabriele, Barth Stefan, Herling Marco

Abstract excerpt

The serine/threonine death-associated protein kinases (DAPK) provide pro-death signals in response to (oncogenic) cellular stresses. Lost DAPK expression due to (epi)genetic silencing is found in a broad spectrum of cancers. Within B-cell lymphomas, deficiency of the prototypic family member DAPK1 represents a predisposing or early tumorigenic lesion and high-frequency promoter methylation marks more aggressive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Source

Identifiers

PMID: 26826117
DOI: 10.1158/1535-7163.MCT-15-0685

Genes

DAPK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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