Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evidence That Cingulin Regulates Endothelial Barrier Function In Vitro and In Vivo.

Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2016

Schossleitner Klaudia, Rauscher Sabine, Gröger Marion, Friedl Heinz Peter, Finsterwalder Richard, Habertheuer Andreas, Sibilia Maria, Brostjan Christine, Födinger Dagmar, Citi Sandra, Petzelbauer Peter

Abstract excerpt

OBJECTIVE: Cingulin is a cytoplasmic component of tight junctions. Although modulation of cingulin levels in cultured epithelial model systems has no significant effect on barrier function, evidence from cingulin knockout mice suggests that cingulin may be involved in the regulation of the behavior of epithelial or endothelial cells. Here, we investigate the role of cingulin in the barrier function of endothelial...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood-Brain Barrier
Share to Capillary Permeability

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Electric Impedance

Share to Endothelial Cells

Share to Purkinje Cells

Share to Rho Guanine Nucleotide Exchange Factors

Share to Tight Junctions

Share to Zonula Occludens-1 Protein

Source

Identifiers

PMID: 26821949
DOI: 10.1161/ATVBAHA.115.307032

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence That Cingulin Regulates Endothelial Barrier Function In Vitro and In Vivo.PMID 26821949Read ↗

Role of Cingulin in Agonist-induced Vascular Endothelial Permeability.Semantic proximity Read ↗

The blood–brain and gut–vascular barriers: from the perspective of claudinsSemantic proximity Read ↗

The region‐selective regulation of endothelial claudin‐5 expression and signaling in brain health and disordersSemantic proximity Read ↗

Decreased filamentous actin and tight junction protein expression, and paracellular permeability in Frataxin-deficient human brain microvascular endothelial cells – implications for blood-brain barrier integrity in Friedreich's AtaxiaSemantic proximity Read ↗

The control of vascular integrity by endothelial cell junctions: molecular basis and pathological implications.Semantic proximity Read ↗

Glut1/SLC2A1 is crucial for the development of the blood‐brain barrier in vivoSemantic proximity Read ↗

Junctional proteins of the blood-brain barrier: New insights into function and dysfunction.Semantic proximity Read ↗

The tight junction protein cingulin regulates gene expression and RhoA signaling.Semantic proximity Read ↗

Astrocytic and endothelial GLUT1 restoration improves brain glucose homeostasis in GLUT1 deficiency syndromeSemantic proximity Read ↗

Aging-regulated TUG1 is dispensable for endothelial cell functionSemantic proximity Read ↗

Loss of Endothelial TDP-43 Leads to Blood Brain Barrier Defects in Mouse Models of Amyotrophic Lateral Sclerosis and Frontotemporal DementiaSemantic proximity Read ↗

Argininosuccinate lyase deficiency causes blood-brain barrier disruption via nitric oxide–mediated dysregulation of claudin expressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.