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Article

The tight junction protein cingulin regulates gene expression and RhoA signaling.

Annals of the New York Academy of Sciences - 1 May 2009

Citi Sandra, Paschoud Serge, Pulimeno Pamela, Timolati Francesco, De Robertis Fabrizio, Jond Lionel, Guillemot Laurent

Abstract excerpt

Tight junctions (TJ) regulate the passage of solutes across epithelial sheets, contribute to the establishment and maintenance of epithelial apico-basal polarity and are involved in the regulation of gene expression and cell proliferation. Cingulin, a Mr 140 kDa protein localized in the cytoplasmic region of TJ, is not directly required for TJ formation and epithelial polarity but regulates RhoA signaling,...

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PMID: 19538293
DOI: 10.1111/j.1749-6632.2009.04053.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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