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Article

Sequencing of FTO and ALKBH5 in men undergoing infertility work-up identifies an infertility-associated variant and two missense mutations.

Fertility and sterility - 1 May 2016

Landfors Miriam, Nakken Sigve, Fusser Markus, Dahl John-Arne, Klungland Arne, Fedorcsak Peter

Abstract excerpt

OBJECTIVE: To assess whether men with reduced semen quality exhibit genetic variants in the genes coding for the messenger RNA methylation erasers FTO and ALKBH5. DESIGN: DNA of men undergoing infertility work-up was extracted and the FTO and ALKBH5 genes were sequenced. Statistical analysis was used to study the correlation between the identified ALKBH5 and FTO variants and sperm quality. SETTING: University...

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Topics

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Share to Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Share to Infertility, Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation, Missense

Share to Protein Structure, Secondary

Share to Semen Analysis

Share to Sequence Analysis, DNA

Share to Spermatozoa

Source

Identifiers

PMID: 26820768
DOI: 10.1016/j.fertnstert.2016.01.002

Genes

FTO
ALKBH5

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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