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Article

Age-Associated Proteomic Changes in Human Spermatozoa

25 Jun 2025

Abstract excerpt

Advancing age in men significantly contributes to declining sperm fertility. Information on age-related proteomic changes in spermatozoa is limited. This study involved normal fertile Arab men in three age groups: young adult (21–30 years; n = 6), late adult (31–40 years; n = 7), and advanced age (40–51 years; n = 5). Gradient-purified spermatozoa were analyzed using LC-MS/MS and proteomic data were processed...

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PMID: 40649876
DOI: 10.3390/ijms26136099

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