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Article

A Computational Protein Phenotype Prediction Approach to Analyze the Deleterious Mutations of Human MED12 Gene.

Journal of cellular biochemistry - 1 Sept 2016

Banaganapalli Babajan, Mohammed Kaleemuddin, Khan Imran Ali, Al-Aama Jumana Y, Elango Ramu, Shaik Noor Ahmad

Abstract excerpt

Genetic mutations in MED12, a subunit of Mediator complex are seen in a broad spectrum of human diseases. However, the underlying basis of how these pathogenic mutations elicit protein phenotype changes in terms of 3D structure, stability and protein binding sites remains unknown. Therefore, we aimed to investigate the structural and functional impacts of MED12 mutations, using computational methods as an...

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Identifiers

PMID: 26813965
DOI: 10.1002/jcb.25499

Genes

MED12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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