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Article

HA stabilization promotes replication and transmission of swine H1N1 gamma influenza viruses in ferrets

25 Jun 2020

Abstract excerpt

Pandemic influenza A viruses can emerge from swine, an intermediate host that supports adaptation of human-preferred receptor-binding specificity by the hemagglutinin (HA) surface antigen. Other HA traits necessary for pandemic potential are poorly understood. For swine influenza viruses isolated in 2009-2016, gamma-clade viruses had less stable HA proteins (activation pH 5.5-5.9) than pandemic clade (pH...

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PMID: 32602461
DOI: 10.7554/elife.56236

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