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Article

Bone matrix hypermineralization in prolyl-3 hydroxylase 1 deficient mice.

Bone - 1 Apr 2016

Fratzl-Zelman Nadja, Bächinger Hans-Peter, Vranka Janice A, Roschger Paul, Klaushofer Klaus, Rauch Frank

Abstract excerpt

Lack of prolyl 3-hydroxylase 1 (P3H1) due to mutations in P3H1 results in severe forms of recessive osteogenesis imperfecta. In the present study, we investigated the bone tissue characteristics of P3H1 null mice. Histomorphometric analyses of cancellous bone in the proximal tibia and lumbar vertebra in 1-month and 3-month old mice demonstrated that P3H1 deficient mice had low trabecular bone volume and low...

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Identifiers

PMID: 26808442
DOI: 10.1016/j.bone.2016.01.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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