Article
Torsin ATPases: structural insights and functional perspectives.
Current opinion in cell biology - 1 Jun 2016
Laudermilch Ethan, Schlieker Christian
Abstract excerpt
Torsin ATPases are the only members of the AAA+ ATPase family that localize to the endoplasmic reticulum and contiguous perinuclear space. Accordingly, they are well positioned to perform essential work in these compartments, but their precise functions remain elusive. Recent studies have deciphered an unusual ATPase activation mechanism relying on Torsin-associated transmembrane cofactors, LAP1 or LULL1. These...
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