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Article

Dynamic functional assembly of the Torsin AAA+ ATPase and its modulation by LAP1.

Molecular biology of the cell - 15 Oct 2017

Chase Anna R, Laudermilch Ethan, Wang Jimin, Shigematsu Hideki, Yokoyama Takeshi, Schlieker Christian

Abstract excerpt

TorsinA is an essential AAA+ ATPase requiring LAP1 or LULL1 as cofactors. The dynamics of the Torsin/cofactor system remain poorly understood, with previous models invoking Torsin/cofactor assemblies with fixed stoichiometries. Here we demonstrate that TorsinA assembles into homotypic oligomers in the presence of ATP. Torsin variants mutated at the "back" interface disrupt homo-oligomerization but still show...

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Identifiers

PMID: 28814508
DOI: 10.1091/mbc.E17-05-0281
PMCID: PMC5638581

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