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Article

Arresting a Torsin ATPase reshapes the endoplasmic reticulum.

The Journal of biological chemistry - 3 Jan 2014

Rose April E, Zhao Chenguang, Turner Elizabeth M, Steyer Anna M, Schlieker Christian

Abstract excerpt

Torsins are membrane-tethered AAA+ ATPases residing in the nuclear envelope (NE) and endoplasmic reticulum (ER). Here, we show that the induction of a conditional, dominant-negative TorsinB variant provokes a profound reorganization of the endomembrane system into foci containing double membrane structures that are derived from the ER. These double-membrane sinusoidal structures are formed by compressing the ER...

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Identifiers

PMID: 24275647
DOI: 10.1074/jbc.M113.515791
PMCID: PMC3879577

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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