Article
Purifying Selection on Exonic Splice Enhancers in Intronless Genes.
Molecular biology and evolution - 1 Jun 2016
Savisaar Rosina, Hurst Laurence D
Abstract excerpt
Exonic splice enhancers (ESEs) are short nucleotide motifs, enriched near exon ends, that enhance the recognition of the splice site and thus promote splicing. Are intronless genes under selection to avoid these motifs so as not to attract the splicing machinery to an mRNA that should not be spliced, thereby preventing the production of an aberrant transcript? Consistent with this possibility, we find that ESEs...
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