Article
Helicase-like transcription factor is a RUNX1 target whose downregulation promotes genomic instability and correlates with complex cytogenetic features in acute myeloid leukemia.
Haematologica - 1 Apr 2016
Cheng Chi Keung, Chan Natalie P H, Wan Thomas S K, Lam Lai Ying, Cheung Coty H Y, Wong Terry H Y, Ip Rosalina K L, Wong Raymond S M, Ng Margaret H L
Abstract excerpt
Helicase-like transcription factor is a SWI/SNF chromatin remodeling factor involved in various biological processes. However, little is known about its role in hematopoiesis. In this study, we measured helicase-like transcription factor mRNA expression in the bone marrow of 204 adult patients with de novo acute myeloid leukemia. Patients were dichotomized into low and high expression groups at the median level...
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