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Uridine homeostatic disorder leads to DNA damage and tumorigenesis.

Cancer letters - 28 Mar 2016

Cao Zhe, Ma Jun, Chen Xinchun, Zhou Boping, Cai Chuan, Huang Dan, Zhang Xuewen, Cao Deliang

Abstract excerpt

Uridine is a natural nucleoside precursor of uridine monophosphate in organisms and thus is considered to be safe and is used in a wide range of clinical settings. The far-reaching effects of pharmacological uridine have long been neglected. Here, we report that the homeostatic disorder of uridine is carcinogenic. Targeted disruption (-/-) of murine uridine phosphorylase (UPase) disrupted the homeostasis of...

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PMID: 26801745
DOI: 10.1016/j.canlet.2016.01.007

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