Article
Mutations of Chromatin Structure Regulating Genes in Human Malignancies.
Current protein & peptide science - 1 Jan 2016
Chen Jian, Herlong Franklin H, Stroehlein John R, Mishra Lopa
Abstract excerpt
Chromatin structure regulating processes mediated by the adenosine triphosphate (ATP) - dependent chromatin remodeling complex and the covalent histone-modifying complexes are critical to gene transcriptional control and normal cellular processes, including cell stemness, differentiation, and proliferation. Gene mutations, structural abnormalities, and epigenetic modifications that lead to aberrant expression of...
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