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Article

Age-Correlated Phenotypic Alterations in Cells Isolated From Human Degenerated Intervertebral Discs With Contained Hernias.

Spine - 1 Mar 2018

Molinos Maria, Cunha Carla, Almeida Catarina R, Gonçalves Raquel M, Pereira Paulo, Silva Pedro Santos, Vaz Rui, Barbosa Mário A

Abstract excerpt

STUDY DESIGN: Human intervertebral disc (hIVD) cells were isolated from 41 surgically excised samples and assessed for their phenotypic alterations with age. OBJECTIVE: Toward the design of novel anti-aging strategies to overcome degenerative disc disease (DDD), we investigated age-correlated phenotypic alterations that occur on primary hIVD cells. SUMMARY OF BACKGROUND DATA: Although regenerative medicine holds...

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Identifiers

PMID: 28678109
DOI: 10.1097/BRS.0000000000002311

Genes

IVD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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