Article
The new β amyloid-derived peptide Aβ1-6A2V-TAT(D) prevents Aβ oligomer formation and protects transgenic C. elegans from Aβ toxicity.
Neurobiology of disease - 1 Apr 2016
Diomede Luisa, Romeo Margherita, Cagnotto Alfredo, Rossi Alessandro, Beeg Marten, Stravalaci Matteo, Tagliavini Fabrizio, Di Fede Giuseppe, Gobbi Marco, Salmona Mario
Abstract excerpt
One attractive pharmacological strategy for Alzheimer's disease (AD) is to design small peptides to interact with amyloid-β (Aβ) protein reducing its aggregation and toxicity. Starting from clinical observations indicating that patients coding a mutated Aβ variant (AβA2V) in the heterozygous state do not develop AD, we developed AβA2V synthetic peptides, as well as a small peptide homologous to residues 1-6....
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