Article
Serum aminotransferases in nonalcoholic fatty liver disease are a signature of liver metabolic perturbations at the amino acid and Krebs cycle level.
The American journal of clinical nutrition - 1 Feb 2016
Sookoian Silvia, Castaño Gustavo O, Scian Romina, Fernández Gianotti Tomas, Dopazo Hernán, Rohr Cristian, Gaj Graciela, San Martino Julio, Sevic Ina, Flichman Diego, Pirola Carlos J
Abstract excerpt
BACKGROUND: Extensive epidemiologic studies have shown that cardiovascular disease and the metabolic syndrome (MetS) are associated with serum concentrations of liver enzymes; however, fundamental characteristics of this relation are currently unknown. OBJECTIVE: We aimed to explore the role of liver aminotransferases in nonalcoholic fatty liver disease (NAFLD) and MetS. DESIGN: Liver gene- and protein-expression...
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