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Article

Epidemiological and Mendelian Randomization Studies of Dihydrotestosterone and Estradiol and Leukocyte Telomere Length in Men.

The Journal of clinical endocrinology and metabolism - 1 Mar 2016

Yeap Bu B, Knuiman Matthew W, Divitini Mark L, Hui Jennie, Arscott Gillian M, Handelsman David J, McLennan Susan V, Twigg Stephen M, McQuillan Brendan, Hung Joseph, Beilby John P

Abstract excerpt

CONTEXT: Advancing age is accompanied by an accumulation of ill health and shortening of chromosomal telomeres signifying biological aging. T is metabolized to DHT by 5α-reductase (SRD5A2) and to estradiol (E2) by aromatase (CYP19A1). Telomerase preserves telomeres, and T and E2 regulate telomerase expression and activity in vitro. OBJECTIVE: The objective of the study was to establish whether circulating T or...

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PMID: 26789780
DOI: 10.1210/jc.2015-4139

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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