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Article

Phase variation of a Type IIG restriction-modification enzyme alters site-specific methylation patterns and gene expression in Campylobacter jejuni strain NCTC11168.

Nucleic acids research - 2 Jun 2016

Anjum Awais, Brathwaite Kelly J, Aidley Jack, Connerton Phillippa L, Cummings Nicola J, Parkhill Julian, Connerton Ian, Bayliss Christopher D

Abstract excerpt

Phase-variable restriction-modification systems are a feature of a diverse range of bacterial species. Stochastic, reversible switches in expression of the methyltransferase produces variation in methylation of specific sequences. Phase-variable methylation by both Type I and Type III methyltransferases is associated with altered gene expression and phenotypic variation. One phase-variable gene of Campylobacter...

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Identifiers

PMID: 26786317
DOI: 10.1093/nar/gkw019
PMCID: PMC4889913

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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