Article
A vacuolar iron-transporter homologue acts as a detoxifier in Plasmodium.
Nature communications - 20 Jan 2016
Slavic Ksenija, Krishna Sanjeev, Lahree Aparajita, Bouyer Guillaume, Hanson Kirsten K, Vera Iset, Pittman Jon K, Staines Henry M, Mota Maria M
Abstract excerpt
Iron is an essential micronutrient but is also highly toxic. In yeast and plant cells, a key detoxifying mechanism involves iron sequestration into intracellular storage compartments, mediated by members of the vacuolar iron-transporter (VIT) family of proteins. Here we study the VIT homologue from the malaria parasites Plasmodium falciparum (PfVIT) and Plasmodium berghei (PbVIT). PfVIT-mediated iron transport in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.