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Article

Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice

3 Dec 2015

Abstract excerpt

In developing hearts, changes in the cardiac metabolic milieu during the perinatal period redirect mitochondrial substrate preference from carbohydrates to fatty acids. Mechanisms responsible for this mitochondrial plasticity are unknown. Here, we found that PINK1-Mfn2-Parkin-mediated mitophagy directs this metabolic transformation in mouse hearts. A mitofusin (Mfn) 2 mutant lacking PINK1 phosphorylation sites...

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PMID: 26785495
DOI: 10.1126/science.aad2459

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