Article
Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis.
Nature genetics - 1 Dec 2012
Whitcomb David C, LaRusch Jessica, Krasinskas Alyssa M, Klei Lambertus, Smith Jill P, Brand Randall E, Neoptolemos John P, Lerch Markus M, Tector Matt, Sandhu Bimaljit S, Guda Nalini M, Orlichenko Lidiya, Alkaade Samer, Amann Stephen T, Anderson Michelle A, Baillie John, Banks Peter A, Conwell Darwin, Coté Gregory A, Cotton Peter B, DiSario James, Farrer Lindsay A, Forsmark Chris E, Johnstone Marianne, Gardner Timothy B, Gelrud Andres, Greenhalf William, Haines Jonathan L, Hartman Douglas J, Hawes Robert A, Lawrence Christopher, Lewis Michele, Mayerle Julia, Mayeux Richard, Melhem Nadine M, Money Mary E, Muniraj Thiruvengadam, Papachristou Georgios I, Pericak-Vance Margaret A, Romagnuolo Joseph, Schellenberg Gerard D, Sherman Stuart, Simon Peter, Singh Vijay P, Slivka Adam, Stolz Donna, Sutton Robert, Weiss Frank Ulrich, Wilcox C Mel, Zarnescu Narcis Octavian, Wisniewski Stephen R, O'Connell Michael R, Kienholz Michelle L, Roeder Kathryn, Barmada M Michael, Yadav Dhiraj, Devlin Bernie
Abstract excerpt
Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now repo...
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