Article
Animal models of scleroderma: current state and recent development.
Current rheumatology reports - 1 Dec 2013
Asano Yoshihide, Sato Shinichi
Abstract excerpt
Systemic sclerosis (SSc) is a multisystem connective tissue disease characterized by three cardinal features: immunological abnormalities, vasculopathy, and fibrosis of skin and certain internal organs. Although several animal models recapitulating selected aspects of SSc have been reported, the absence of models fulfilling the full clinical picture of SSc has hindered progress in the development and testing of...
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