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Article

Genomic island 2 is an unstable genetic element contributing to Brucella lipopolysaccharide spontaneous smooth-to-rough dissociation.

Journal of bacteriology - 1 Dec 2010

Mancilla Marcos, López-Goñi Ignacio, Moriyón Ignacio, Zárraga Ana María

Abstract excerpt

Brucella is a Gram-negative bacterium that causes a worldwide-distributed zoonosis. The genus includes smooth (S) and rough (R) species that differ in the presence or absence, respectively, of the O-polysaccharide of lipopolysaccharide. In S brucellae, the O-polysaccharide is a critical diagnostic antigen and a virulence determinant. However, S brucellae spontaneously dissociate into R forms, a problem in antigen...

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Identifiers

PMID: 20952568
DOI: 10.1128/JB.00838-10
PMCID: PMC3008527

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Source receipt: pubmed, retrieved 7 Sept 2026.

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