Article
Genomic variant in CAV1 increases susceptibility to coronary artery disease and myocardial infarction.
Atherosclerosis - 1 Mar 2016
Chen Shanshan, Wang Xiaojing, Wang Junhan, Zhao Yuanyuan, Wang Dan, Tan Chengcheng, Fa Jingjing, Zhang Rongfeng, Wang Fan, Xu Chaoping, Huang Yufeng, Li Sisi, Yin Dan, Xiong Xin, Li Xiuchun, Chen Qiuyun, Tu Xin, Yang Yanzong, Xia Yonglong, Xu Chengqi, Wang Qing K
Abstract excerpt
BACKGROUND: The CAV1 gene encodes caveolin-1 expressed in cell types relevant to atherosclerosis. Cav-1-null mice showed a protective effect on atherosclerosis under the ApoE(-/-) background. However, it is unknown whether CAV1 is linked to CAD and MI in humans. In this study we analyzed a tagSNP for CAV1 in intron 2, rs3807989, for potential association with CAD. METHODS AND RESULTS: We performed case-control...
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