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Article

IL-10 from marginal zone precursor B cells controls the differentiation of Th17, Tfh and Tfr cells in transplantation tolerance.

Immunology letters - 1 Feb 2016

Lal Girdhari, Kulkarni Neeraja, Nakayama Yumi, Singh Amit K, Sethi Apoorva, Burrell Bryna E, Brinkman C Colin, Iwami Daiki, Zhang Tianshu, Hehlgans Thomas, Bromberg Jonathan S

Abstract excerpt

B cells are known to control CD4T cell differentiation in secondary lymphoid tissues. We hypothesized that IL-10 expression by marginal zone precursor (MZP) regulatory B cells controls the differentiation and positioning of effector and regulatory T cells during tolerization. Costimulatory blockade with donor-specific transfusion (DST) and anti-CD40L mAb in C57BL/6 mice induced tolerance to allogeneic cardiac...

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Identifiers

PMID: 26772435
DOI: 10.1016/j.imlet.2016.01.002
PMCID: PMC4740190

Genes

CCR6
DST

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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