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Article

Poly(ADP-ribosyl)ation of Methyl CpG Binding Domain Protein 2 Regulates Chromatin Structure.

The Journal of biological chemistry - 4 Mar 2016

Becker Annette, Zhang Peng, Allmann Lena, Meilinger Daniela, Bertulat Bianca, Eck Daniel, Hofstaetter Maria, Bartolomei Giody, Hottiger Michael O, Schreiber Valérie, Leonhardt Heinrich, Cardoso M Cristina

Abstract excerpt

The epigenetic information encoded in the genomic DNA methylation pattern is translated by methylcytosine binding proteins like MeCP2 into chromatin topology and structure and gene activity states. We have shown previously that the MeCP2 level increases during differentiation and that it causes large-scale chromatin reorganization, which is disturbed by MeCP2 Rett syndrome mutations. Phosphorylation and other...

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Identifiers

PMID: 26772194
DOI: 10.1074/jbc.M115.698357
PMCID: PMC4777825

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Poly(ADP-ribosyl)ation of Methyl CpG Binding Domain Protein 2 Regulates Chromatin Structure.PMID 26772194Read ↗

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MeCP2 binds cooperatively to its substrate and competes with histone H1 for chromatin binding sites.Semantic proximity Read ↗

MeCP2, A Modulator of Neuronal Chromatin Organization Involved in Rett Syndrome.Semantic proximity Read ↗

From Function to Phenotype: Impaired DNA Binding and Clustering Correlates with Clinical Severity in Males with Missense Mutations in MECP2.Semantic proximity Read ↗

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Analysis of protein domains and Rett syndrome mutations indicate that multiple regions influence chromatin-binding dynamics of the chromatin-associated protein MECP2 in vivo.Semantic proximity Read ↗

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