Article
Allele-specific recognition by LILRB3 and LILRA6 of a cytokeratin 8-associated ligand on necrotic glandular epithelial cells.
Oncotarget - 29 Mar 2016
Jones Des C, Hewitt Colin R A, López-Álvarez María R, Jahnke Martin, Russell Alasdair I, Radjabova Valeria, Trowsdale Alice R Z, Trowsdale John
Abstract excerpt
The LILRs are a family of receptors that regulate the activities of myelomonocytic cells. We found that specific allelic variants of two related members of the LILR family, LILRB3 and LILRA6, interact with a ligand exposed on necrotic glandular epithelial cells. The extracellular domains of LILRB3 and LILRA6 are very similar and their genes are highly polymorphic. A commonly occurring allele, LILRB3*12, displayed...
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