Article
Association of IL-13 gene polymorphisms with airway hyperresponsiveness in a Japanese adult asthmatic population.
Respiratory investigation - 1 Sept 2013
Utsumi Yu, Sasaki Nobuhito, Nagashima Hiromi, Suzuki Naomi, Nakamura Yutaka, Yamashita Masahiro, Kobayashi Hitoshi, Yamauchi Kohei
Abstract excerpt
BACKGROUND: A single nucleotide polymorphism (SNP; rs20541) in the IL-13 gene has been recognized as a risk factor for asthma. This SNP causes Arg to Gln (Q) substitution at position 110 in the mature IL-13 protein. We have recently showed that FEV1 in asthmatics with the Q110 variant of IL-13 declined faster, and progressive airway remodeling was observed in these subjects (Wynn, 2003 [1]). However, the effects...
Topics
- Adult
- Aged
- Aged, 80 and over
- Airway Remodeling
- Amino Acid Substitution
- Asian People
- Asthma
- Bronchial Hyperreactivity