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Article

Correction of Hair Shaft Defects through Allele-Specific Silencing of Mutant Krt75.

The Journal of investigative dermatology - 1 Jan 2016

Liu Ying, Snedecor Elizabeth R, Zhang Xu, Xu Yanfeng, Huang Lan, Jones Evan C, Zhang Lianfeng, Clark Richard A, Roop Dennis R, Qin Chuan, Chen Jiang

Abstract excerpt

Dominant mutations in keratin genes can cause a number of inheritable skin disorders characterized by intraepidermal blistering, epidermal hyperkeratosis, or abnormalities in skin appendages, such as nail plate dystrophy and structural defects in hair. Allele-specific silencing of mutant keratins through RNA interference is a promising therapeutic approach for suppressing the expression of mutant keratins and...

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Identifiers

PMID: 26763422
DOI: 10.1038/JID.2015.375
PMCID: PMC4764097

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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