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Article

The mitochondrial carrier Rim2 co-imports pyrimidine nucleotides and iron.

The Biochemical journal - 1 Oct 2013

Froschauer Elisabeth M, Rietzschel Nicole, Hassler Melanie R, Binder Markus, Schweyen Rudolf J, Lill Roland, Mühlenhoff Ulrich, Wiesenberger Gerlinde

Abstract excerpt

Mitochondrial iron uptake is of key importance both for organelle function and cellular iron homoeostasis. The mitochondrial carrier family members Mrs3 and Mrs4 (homologues of vertebrate mitoferrin) function in organellar iron supply, yet other low efficiency transporters may exist. In Saccharomyces cerevisiae, overexpression of RIM2 (MRS12) encoding a mitochondrial pyrimidine nucleotide transporter can overcome...

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PMID: 23800229
DOI: 10.1042/BJ20130144

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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