Article
Hypoxia-inducible factor 1 upregulation of both VEGF and ANGPTL4 is required to promote the angiogenic phenotype in uveal melanoma.
Oncotarget - 16 Feb 2016
Hu Ke, Babapoor-Farrokhran Savalan, Rodrigues Murilo, Deshpande Monika, Puchner Brooks, Kashiwabuchi Fabiana, Hassan Syed Junaid, Asnaghi Laura, Handa James T, Merbs Shannath, Eberhart Charles G, Semenza Gregg L, Montaner Silvia, Sodhi Akrit
Abstract excerpt
PURPOSE: Expression of the hypoxia-inducible factor (HIF)-1-regulated gene product, vascular endothelial growth factor (VEGF), correlates with tumor vascularity in patients with uveal melanoma (UM). While the relationship between HIF-1 and VEGF in cancer is well-studied, their relative contribution to the angiogenic phenotype in UM has not previously been interrogated. Here we evaluate the contribution of HIF-1,...
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