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Article

Hypoxia-Inducible Factor-Dependent Expression of Angiopoietin-Like 4 by Conjunctival Epithelial Cells Promotes the Angiogenic Phenotype of Pterygia.

Investigative ophthalmology & visual science - 1 Sept 2017

Meng Qianli, Qin Yaowu, Deshpande Monika, Kashiwabuchi Fabiana, Rodrigues Murilo, Lu Qiaozhi, Ren Hui, Elisseeff Jennifer H, Semenza Gregg L, Montaner Silvia V, Sodhi Akrit

Abstract excerpt

Purpose: Disappointing results from clinical studies assessing the efficacy of therapies targeting vascular endothelial growth factor (VEGF) for the treatment of pterygia suggest that other angiogenic mediators may also play a role in its development. We therefore explore the relative contribution of VEGF, hypoxia-inducible factor (HIF)-1α (the transcription factor that regulates VEGF expression in ocular...

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Source

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Identifiers

PMID: 28873177
DOI: 10.1167/iovs.17-21974
PMCID: PMC5584708

Genes

ANGPTL4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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