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Article

PARP inhibition promotes endothelial-like traits in melanoma cells and modulates pericyte coverage dynamics during vasculogenic mimicry.

The Journal of pathology - 1 Mar 2023

Fernández-Cortés Mónica, Delgado-Bellido Daniel, Bermúdez-Jiménez Eloísa, Paramio Jesús M, O'Valle Francisco, Vinckier Stefan, Carmeliet Peter, Garcia-Diaz Angel, Oliver F Javier

Abstract excerpt

Vasculogenic mimicry (VM) describes the ability of highly aggressive tumor cells to develop pseudovascular structures without the participation of endothelial cells. PARP1 is implicated in the activation of hypoxia-inducible factors, which are crucial in tumor neovascularization. We have explored the role of hypoxia and PARP inhibition in VM. In uveal melanoma xenografts, the PARP inhibitor olaparib improved in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36484652
DOI: 10.1002/path.6043
PMCID: PMC10107856

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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