Article

Regulated extracellular matrix trafficking shapes cell growth during cartilage morphogenesis

2022-06-10

Abstract excerpt

Craniofacial malformations are present in more than one third of all congenital syndromes, but the pathogenesis of skeletal dysmorphology is poorly understood. Here, using an unbiased forward genetics approach in zebrafish, we identified a mutation in erc1b that leads to craniofacial defects, including micrognathia and hypertelorism caused by impaired cartilage and bone growth. To date, ERC1 has not been conside...

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Literature Corpus work: 5ce9703e-7537-577d-9730-adf6e0c5235c
DOI: 10.1101/2022.06.08.495337

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