Phenotypic and genomic analysis of multiple myeloma minimal residual disease tumor cells: a new model to understand chemoresistance.

doi:10.1182/blood-2015-08-665679

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Article

Phenotypic and genomic analysis of multiple myeloma minimal residual disease tumor cells: a new model to understand chemoresistance.

Blood - 14 Apr 2016

Paiva Bruno, Corchete Luis A, Vidriales Maria-Belen, Puig Noemi, Maiso Patricia, Rodriguez Idoia, Alignani Diego, Burgos Leire, Sanchez Maria-Luz, Barcena Paloma, Echeveste Maria-Asuncion, Hernandez Miguel T, García-Sanz Ramón, Ocio Enrique M, Oriol Albert, Gironella Mercedes, Palomera Luis, De Arriba Felipe, Gonzalez Yolanda, Johnson Sarah K, Epstein Joshua, Barlogie Bart, Lahuerta Juan José, Blade Joan, Orfao Alberto, Mateos María-Victoria, San Miguel Jesús F

Abstract excerpt

Persistence of chemoresistant minimal residual disease (MRD) plasma cells (PCs) is associated with inferior survival in multiple myeloma (MM). Thus, characterization of the minor MRD subclone may represent a unique model to understand chemoresistance, but to our knowledge, the phenotypic and genetic features of the MRD subclone have never been investigated. Here, we compared the antigenic profile of MRD vs...

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PMID: 26755711
DOI: 10.1182/blood-2015-08-665679

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ALCAM
CXCR4

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