Article
Immunophenotypic heterogeneity of normal plasma cells: comparison with minimal residual plasma cell myeloma.
Journal of clinical pathology - 1 Sept 2012
Liu Dingsheng, Lin Pei, Hu Ying, Zhou Yi, Tang Guilin, Powers Linda, Medeiros L Jeffrey, Jorgensen Jeffrey L, Wang Sa A
Abstract excerpt
Plasma cell myeloma (PCM) exhibits immunophenotypic aberrancies that can be used for minimal residual disease (MRD) detection after therapy. The authors sought to determine whether non-neoplastic plasma cells, especially in the bone marrow (BM) post various therapies, would exhibit immunophenotypic variations interfering PCM MRD detection. The authors studied the flow cytometric immunophenotypes of non-neoplastic...
Topics
- Adult
- Aged
- Aged, 80 and over
- Antigens, CD
- Antigens, CD19
- Antigens, CD20
- Biomarkers
- Bone Marrow
- Bone Marrow Examination
- CD28 Antigens
- Female
- Flow Cytometry
- Humans
- Immunoglobulin gamma-Chains