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Article

Epigenetic and oncogenic regulation of SLC16A7 (MCT2) results in protein over-expression, impacting on signalling and cellular phenotypes in prostate cancer.

Oncotarget - 28 Aug 2015

Pertega-Gomes Nelma, Vizcaino Jose R, Felisbino Sergio, Warren Anne Y, Shaw Greg, Kay Jonathan, Whitaker Hayley, Lynch Andy G, Fryer Lee, Neal David E, Massie Charles E

Abstract excerpt

Monocarboxylate Transporter 2 (MCT2) is a major pyruvate transporter encoded by the SLC16A7 gene. Recent studies pointed to a consistent overexpression of MCT2 in prostate cancer (PCa) suggesting MCT2 as a putative biomarker and molecular target. Despite the importance of this observation the mechanisms involved in MCT2 regulation are unknown. Through an integrative analysis we have discovered that selective...

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Identifiers

PMID: 26035357
DOI: 10.18632/oncotarget.4328
PMCID: PMC4673295

Genes

ERG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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