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Article

Type 1 diabetes: translating mechanistic observations into effective clinical outcomes.

Nature reviews. Immunology - 1 Apr 2013

Herold Kevan C, Vignali Dario A A, Cooke Anne, Bluestone Jeffrey A

Abstract excerpt

Type 1 diabetes (T1D) remains an important health problem, particularly in western countries, where the incidence has been increasing in younger children. In 1986, Eisenbarth described T1D as a chronic autoimmune disease. Work over the past three-and-a-half decades has identified many of the genetic, immunological and environmental factors that are involved in the disease and have led to hypotheses concerning its...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 23524461
DOI: 10.1038/nri3422
PMCID: PMC4172461

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