Coagulase and Efb of Staphylococcus aureus Have a Common Fibrinogen Binding Motif

doi:10.1128/mbio.01885-15

Article

Coagulase and Efb of Staphylococcus aureus Have a Common Fibrinogen Binding Motif

29 Jan 2016

Abstract excerpt

UNLABELLED: Coagulase (Coa) and Efb, secreted Staphylococcus aureus proteins, are important virulence factors in staphylococcal infections. Coa interacts with fibrinogen (Fg) and induces the formation of fibrin(ogen) clots through activation of prothrombin. Efb attracts Fg to the bacterial surface and forms a shield to protect the bacteria from phagocytic clearance. This communication describes the use of an...

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