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Article

Structural and biochemical characterization of Staphylococcus aureus clumping factor B/ligand interactions.

The Journal of biological chemistry - 22 Jul 2011

Ganesh Vannakambadi K, Barbu E Magda, Deivanayagam Champion C S, Le Binh, Anderson Analiesa S, Matsuka Yury V, Lin Shuo L, Foster Timothy J, Narayana Sthanam V L, Höök Magnus

Abstract excerpt

Clumping factor B (ClfB) from Staphylococcus aureus is a bifunctional protein that binds to human cytokeratin 10 (K10) and fibrinogen (Fg). ClfB has been implicated in S. aureus colonization of nasal epithelium and is therefore a key virulence factor. People colonized with S. aureus are at an increased risk for invasive staphylococcal disease. In this study, we have determined the crystal structures of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21543319
DOI: 10.1074/jbc.M110.217414
PMCID: PMC3138276

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