Article
Polymorphism of rs2767485 in Leptin Receptor Gene is Associated With the Occurrence of Adolescent Idiopathic Scoliosis.
Spine - 15 Oct 2015
Liu Zhen, Wang Fei, Xu Lei-Lei, Sha Shi-Fu, Zhang Wen, Qiao Jun, Bao Hong-da, Qiu Yong, Jiang Qing, Zhu Ze-Zhang
Abstract excerpt
STUDY DESIGN: A genetic association study of leptin receptor (LEPR) gene with adolescent idiopathic scoliosis (AIS) in the Chinese Han population. OBJECTIVE: To determine whether LEPR gene polymorphisms are associated with the predisposition and/or disease severity of AIS. SUMMARY OF BACKGROUND DATA: Patients with AIS were reported to have lower body mass index (BMI), abnormal leptin bioavailability, and systemic...
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