Article
A single-nucleotide polymorphism rs708567 in the IL-17RC gene is associated with a susceptibility to and the curve severity of adolescent idiopathic scoliosis in a Chinese Han population: a case-control study.
BMC musculoskeletal disorders - 21 Sept 2012
Zhou Song, Qiu Xu-Sheng, Zhu Ze-Zhang, Wu Wei-Fei, Liu Zhen, Qiu Yong
Abstract excerpt
BACKGROUND: Although the pathogenesis of adolescent idiopathic scoliosis (AIS) remains controversial, genetic factors are thought to play key roles in the development of AIS. In a recent genome-wide association study, a polymorphism in the interleukin-17 receptor C (IL-17RC) gene was reported to be associated with the susceptibility to AIS, implicating IL-17RC as a novel predisposing gene for AIS. However, as...
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