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Article

Association of polymorphism in leptin receptor gene with susceptibility of adolescent idiopathic scoliosis.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society - 1 Feb 2024

Araujo Junior Antonio Eulalio Pedrosa, de Azevedo Gustavo Borges Laurindo, Moliterno Luis Antonio Medeiros, Tavares Renato Henriques, Cardoso Jessica Vilarinho, de Souza Giuliana Rodrigues, Guimarães João Antonio Matheus, Defino Helton Luiz Aparecido, Perini Jamila Alessandra

Abstract excerpt

PURPOSE: Abnormal leptin bioavailability has play key roles in the etiology of adolescent idiopathic scoliosis (AIS). Both leptin and its receptor levels may be modulated by the presence of genetic polymorphisms. This study aimed to evaluate the role of polymorphisms in the leptin (LEP) and its main receptor (LEPR) genes in the AIS susceptibility in girls. METHODS: A retrospective case-control study was conducted...

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Adolescent
Case-Control Studies
LEP gene
LEPR gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Receptors, Leptin

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Identifiers

PMID: 37801129
DOI: 10.1007/s00586-023-07955-3

Genes

LEP
LEPR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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