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Article

HPV 16E7 and 48E7 proteins use different mechanisms to target p130 to overcome cell cycle block.

Virology journal - 4 Jan 2016

Nor Rashid Nurshamimi, Yong Zi Ling, Yusof Rohana, Watson Roger J

Abstract excerpt

BACKGROUND: Retinoblastoma like protein 2 (RBL2) or p130 is a member of the pocket protein family, which is infrequently mutated in human tumours. Its expression is posttranscriptionally regulated and largely G0 restricted. We have previously shown that E6/E7 oncoproteins encoded by human papillomavirus (HPV) type 16, which is a high-risk type for cervical cancer development, must target p130 to promote the host...

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Share to Alphapapillomavirus
Share to Amino Acid Motifs
Share to Cell Cycle Checkpoints

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Papillomavirus E7 Proteins

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Share to Protein Interaction Domains and Motifs

Share to Retinoblastoma-Like Protein p130

Source

Open in PubMed Open full text

Identifiers

PMID: 26728921
DOI: 10.1186/s12985-015-0460-8
PMCID: PMC4700559

Genes

CDK2
RBL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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HPV 16E7 and 48E7 proteins use different mechanisms to target p130 to overcome cell cycle block.PMID 26728921Read ↗

Disruption of repressive p130–DREAM complexes by human papillomavirus 16 E6/E7 oncoproteins is required for cell-cycle progression in cervical cancer cellsSemantic proximity Read ↗

Interactions with Pocket Proteins Contribute to the Role of Human Papillomavirus Type 16 E7 in the Papillomavirus Life CycleSemantic proximity Read ↗

Role of LXCXE motif-dependent interactions in the activity of the retinoblastoma protein.Semantic proximity Read ↗

The E7 proteins of low- and high-risk human papillomaviruses share the ability to target the pRB family member p130 for degradationSemantic proximity Read ↗

Induction of pRb Degradation by the Human Papillomavirus Type 16 E7 Protein Is Essential To Efficiently Overcome p16 <sup>INK4a</sup> -Imposed G <sub>1</sub> Cell Cycle ArrestSemantic proximity Read ↗

Dynamic site-specific recruitment of RBP2 by pocket protein p130 modulates H3K4 methylation on E2F-responsive promoters.Semantic proximity Read ↗

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Mutagenesis of the pRB Pocket Reveals that Cell Cycle Arrest Functions Are Separable from Binding to Viral OncoproteinsSemantic proximity Read ↗

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