Article
Non-invasive Macrophage Tracking Using Novel Porphysome Nanoparticles in the Post-myocardial Infarction Murine Heart.
Molecular imaging and biology - 1 Aug 2016
Ni Nathan C, Jin Cheng S, Cui Liyang, Shao Zhengbo, Wu Jun, Li Shu-Hong, Weisel Richard D, Zheng Gang, Li Ren-Ke
Abstract excerpt
PURPOSE: We generated a folate-conjugated porphyrin nanoparticle (porphysome) suitable for multimodal non-invasive active macrophage tracking post-myocardial infarction (MI). PROCEDURES: Macrophage uptake of folate-conjugated porphysomes was selective. Folate-porphysome cardiac macrophage tracking was detected in vivo using radioligand and fluorescent imaging. To track post-MI macrophage mobilization, cardiac...
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