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Article

Glucose-Raising Polymorphisms in the Human Clock Gene Cryptochrome 2 (CRY2) Affect Hepatic Lipid Content.

PloS one - 1 Jan 2016

Machicao Fausto, Peter Andreas, Machann Jürgen, Königsrainer Ingmar, Böhm Anja, Lutz Stefan Zoltan, Heni Martin, Fritsche Andreas, Schick Fritz, Königsrainer Alfred, Stefan Norbert, Häring Hans-Ulrich, Staiger Harald

Abstract excerpt

Circadian rhythms govern vital functions. Their disruption provokes metabolic imbalance favouring obesity and type-2 diabetes. The aim of the study was to assess the role of clock genes in human prediabetes. To this end, genotype-phenotype associations of 121 common single nucleotide polymorphisms (SNPs) tagging ARNTL, ARNTL2, CLOCK, CRY1, CRY2, PER1, PER2, PER3, and TIMELESS were assessed in a study population...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26726810
DOI: 10.1371/journal.pone.0145563
PMCID: PMC4699770

Genes

CRY2
CLOCK
CRY1
PER1
PER2
PER3
TIMELESS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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