Article
Identification of c-kit mutations-independent neoplastic cell proliferation of canine mast cells.
Veterinary immunology and immunopathology - 15 Nov 2008
Ohmori Keitaro, Kawarai Shinpei, Yasuda Nobutaka, Tanaka Akane, Matsuda Hiroshi, Nishimura Ryohei, Sasaki Nobuo, Tsujimoto Hajime, Masuda Kenichi
Abstract excerpt
Gain-of-function mutations in the proto-oncogene c-kit have been considered the molecular mechanism of neoplastic proliferation of mast cells. However, the importance of c-kit gene mutations is not well evaluated in canine mast cell tumors (MCTs). In the present study, we established and characterized a mast cell line, HRMC, derived from a dog with MCT. We also examined c-kit mutations in HRMC cells and assessed...
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