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Article

Small extracellular vesicle-mediated adipocyte-cardiomyocyte crosstalk exacerbates heart failure with preserved ejection fraction.

Cardiovascular research - 26 Mar 2026

Pan Qi, Chen Cheng, Zhang Ce, Jiang Yao, Zhou Ziqin, Zhang Han, Gillette Thomas G, Hill Joseph A, Schiattarella Gabriele G, Wu Guixin, Yang Yuejin, Chen Guihao

Abstract excerpt

AIMS: Although growing evidence suggests that obesity/central adiposity predisposes to the development and exacerbation of heart failure with preserved ejection fraction (HFpEF), it remains to be clarified whether there is a causal relationship between adiposity and HFpEF pathogenesis. METHODS AND RESULTS: HFpEF was induced in male C57BL/6N mice using a high-fat diet + Nω-nitro-l-arginine methyl ester. Resection...

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Share to Adipocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41645491
DOI: 10.1093/cvr/cvag030

Genes

ULK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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